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Headache recurrence(HR)may occur within 24 hours in approximately 40%of migraine attacks initially treated successfully with 6 mg subcutaneous(SC) sumatriptan.Of 442 assessable patients,82/212 in the sumatriptan-treated group(39%)and 89/230 in the placebo-treated group(39%)reported HR in attack 1.Median times to recurrence were 15.6 hours after sumatriptan and 10.3 hours after placebo(p=0.006).One hundred mg oral sumatriptan taken 4 hours after 6 mg SC sumatriptan does not prevent HR but significantly delays time to recurrence. |
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